Nezih Ziroglu1, Akay Kirat2, Tansu Birinci3

1Department of Orthopedics and Traumatology, Beylikdüzü State Hospital, Istanbul, Turkey
2Department of Orthopedics and Traumatology, Dörtyol State Hospital, Hatay, Turkey
3Department of Physiotherapy and Rehabilitation, Istanbul Medeniyet University, Faculty of Health Sciences, Istanbul, Turkey

Keywords: Ankylosing spondylitis, joint replacement, malignant melanoma, tumor necrosis factor-alpha, wrist arthritis.


Ankylosing spondylitis (AS), which is a chronic inflammatory disease, is the most frequent and severe subtype of seronegative spondyloarthropathies. Although it typically affects the axial skeleton, the spine, peripheral joints, and entheses are frequently involved as well as extra-articular manifestations. In this case report, we present the clinical picture of malignant melanoma on the plantar surface of the foot, which is a rare side effect of anti-tumor necrosis factor therapy, as well as wrist arthritis, a very rare manifestation of AS. In addition, it dramatically illustrates how devastating AS can be for peripheral joints, while demonstrating the impact of arthroplasty and arthrodesis procedures on the patient's functional status.

Citation: Ziroglu N, Kirat A, Birinci T. Wrist arthritis and drug-related malignant melanoma in an ankylosing spondylitis patient: An unusual and rare case report. Jt Dis Relat Surg Case Rep 2022;1(2):67-70.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.